In the jar of a blender, add the salsa, water, lemon juice and Worcestershire sauce. Blend until smooth.
On a small plate, add the salt, chile flake and lime and stir to combine. Wet the rim of 2 tall glasses with a lemon wedge and dip into lime salt mixture. Fill with ice and add tequila and top with the salsa juice. Stir to combine and top with garnishes of choice.